RN Jobs in Knoxville, TN

If you’re looking for contract, temporary, per diem, part-time, or full-time RN jobs, Knoxville, TN, is a great place to find them. Knoxville is a lively mid-sized city tucked between the Cumberland and Smoky Mountains. It’s the largest city in eastern Tennessee and the third-largest in the state.

On top of that, Knoxville is a college town, home to the University of Tennessee and its 38,000-plus students. Learn more about what it’s like to be a nurse in this city.

Quick Facts About RN Positions: Knoxville, TN

Is Tennessee a compact state? Yes, if you have a compact nursing license, you are permitted to work as a nurse here. Read about the Tennessee Nurse Practice Act.
What’s the average pay for RNs in Knoxville? Registered nurses in Knoxville earn about $73,480 per year on average, but your salary will depend on your schedule, location, and experience.
Where can I learn more about Tennessee licensure requirements? Visit the Tennessee Board of Nursing for up-to-date information. If your license is about to expire, check out our three-step guide for Tennessee nursing license renewals.
Where else can I find nursing jobs nearby? Search for openings in these surrounding cities:

What to Know About RN Jobs in Knoxville

Around 198,000 people live in Knoxville, and the median age is almost 34. Residents under 18 and over 65 make up 17% and 16% of the population, respectively. Around 33% of residents are married.

If you’re considering a move to Knoxville, expect to care for patients from a variety of backgrounds and walks of life. Consider brushing up on your cultural competency training to ensure you’re prepared to provide care for all of Knoxville’s residents. Check out a demographic breakdown of Knoxville below:

71% White
15% Black
9% Hispanic or Latino
4% two or more races
2% Asian

Get Your RN Resume and Cover Letter Ready

Before you begin applying for jobs in Knoxville, make sure your RN resume and cover letter are updated and tailored to the roles you’re targeting.

Highlight your clinical strengths, patient care experience, and any specialized skills that set you apart. Don’t forget to list additional qualifications — like certifications, leadership experience, tech proficiency, or relevant non-nursing positions — as these can help your application rise to the top in a competitive market.

Interviewing for Knoxville RN Jobs?

If you’ve landed an interview, reviewing common RN interview questions can help you walk in feeling grounded and prepared. Spend a few minutes learning about the organization’s mission, culture, and the patient populations they serve so you can clearly express why you’re excited about the role. Approach the conversation with curiosity and professionalism — interviews are a two-way evaluation, and it’s just as important for you to determine whether the workplace is a good fit for your goals and values.

Find RN Jobs in Knoxville by Facility

Hospitals in Knoxville, TN, are seeking nurses like you. Healthcare is a leading employment sector in Knoxville, alongside advanced manufacturing, technology, and tourism. See roles by facility below:

Parkwest Medical Center (part of Covenant Health)
East Tennessee Children's Hospital
National HealthCare Corporation (NHC)
Option Care Health
Select Medical
Prisma Health

Let Opportunities Come to You

Looking for RN jobs? Knoxville, TN, isn’t the only area that needs nurses. Whether you’re just curious about what’s out there or you’re actively interviewing, we make it easy to track roles that meet your needs. Sign up for personalized job notifications to learn more.