About Duke University Hospital

Pursue your passion for caring with Duke University Hospital in Durham, North Carolina, which is consistently ranked among the best in the United States. The largest of the four Duke Healthhospitals with 1062 patient beds, it features comprehensive diagnostic and therapeutic facilities, including a regional emergency/trauma center, an endo-surgery center, and more.

Duke Nursing Highlights:

Duke University Health System is designated as a Magnet organization
Nurses from each hospital are consistently recognized each year as North Carolina's Great 100 Nurses.
Duke University Health System was awarded the American Board of Nursing Specialties Award for Nursing Certification Advocacy for being strong advocates of specialty nursing certification.
Duke University Health System has 6000 + registered nurses
Quality of Life: Living in the Triangle!
Relocation Assistance (based on eligibility)

Registered Nurse (New Grads) – Pediatric Transplant & Cellular Therapy/Oncology
Duke University Hospital
Full Time | Day/Night Rotating

Must be willing to start in September or October 2026.

Duke University Health System seeks to hire an experienced Registered Nurse with a passion for high-acuity, relationship-centered pediatric care to join our Pediatric Transplant & Cellular Therapy/Oncology Unit. This team plays a vital role in Duke Children’s mission of Advancing Health Together.

Unit Overview
This 17-bed blended pediatric specialty unit cares for a unique and complex patient population, including:

Stem cell transplant recipients
Cellular therapy patients (including CAR-T)
Pediatric oncology patients with high-risk hematologic malignancies and brain tumors
Children with sickle cell disease, metabolic disorders, and genetic conditions

The unit supports longer-term continuity-based care with an average length of stay of 30 days, allowing nurses to develop deep and meaningful connections with patients and families.

Acuity Level:

Transplant & cellular therapy patients: ICU-level (“ICU light”)
Oncology patients: step-down acuity

Staffing & Support Structure

RN-to-patient ratio: 1:1 to 1:3 depending on acuity
Free-standing charge nurse 24/7 (no patient assignment)
Health Unit Coordinator 24/7
Nursing Assistants/NCAs on unit daily (7a–7p)
Multidisciplinary rounds with active RN collaboration

What You Will Do
As a Clinical Nurse I, you will deliver comprehensive, evidence-based care in alignment with the medical and nursing plans of care. Responsibilities include:

Core Responsibilities

Perform thorough pediatric assessments and ongoing monitoring of high-acuity transplant, cellular therapy, and oncology patients.
Plan, provide, and document individualized nursing care using the nursing process.
Administer chemotherapy, immunotherapy, and supportive regimens.
Provide central line management (Broviac, Port-A-Cath, PICC).
Administer and monitor blood products.
Identify and respond to early signs of clinical deterioration.
Educate patients and families on treatment, expectations, and home care.
Delegate and supervise care delivered by licensed and unlicensed personnel.
Serve as charge nurse or team leader as needed.
Act as a preceptor and support the growth of new staff and learners.
Contribute to clinical and operational performance improvement initiatives.

Specialized Clinical Skills You Will Develop

Chemotherapy certification
Cellular therapy and transplant competencies
Management of:
- Engraftment syndrome
- Graft-versus-host disease (GVHD)
- Cytokine Release Syndrome (CRS)
- Neurotoxicity (ICANS)
Advanced pediatric critical thinking and interdisciplinary communication

What You Can Expect

A fast-paced, highly collaborative environment
Relationship-based nursing with long-term patients and families
Involvement in daily rounds and care planning
Opportunities to grow in one of Duke’s highest-acuity pediatric care settings

What We Provide

Paid training: 6–8 weeks of orientation based on experience
Clinical Ladder advancement opportunities
Tuition assistance
Specialty certification bonus
Performance increases
Relocation assistance
Employee referral program
Comprehensive benefits: Medical, Dental, Vision, Pension, and more
Robust professional development through Duke’s Office of Continuing Education

What You Will Need

Graduation from an accredited BSN, ADN, or Nursing Diploma program.
RNs without a BSN must enroll in a BSN program within 2 years and complete it within 7 years

Licensure & Certifications

Current NC RN license or compact license
BLS certification required

Duke is an Equal Opportunity Employer committed to providing employment opportunity without regard to an individual's age, color, disability, gender, gender expression, gender identity, genetic information, national origin, race, religion, sex (including pregnancy and pregnancy related conditions), sexual orientation or military status.

Duke aspires to create a community built on collaboration, innovation, creativity, and belonging. Our collective success depends on the robust exchange of ideas—an exchange that is best when the rich diversity of our perspectives, backgrounds, and experiences flourishes. To achieve this exchange, it is essential that all members of the community feel secure and welcome, that the contributions of all individuals are respected, and that all voices are heard. All members of our community have a responsibility to uphold these values.

Essential Physical Job Functions:

Certain jobs at Duke University and Duke University Health System may include essential job functions that require specific physical and/or mental abilities. Additional information and provision for requests for reasonable accommodation will be provided by each hiring department.

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